Inflammatory myofibroblastic tumor histology
Inflammatory myofibroblastic tumor histology. IMT is a benign and uncommon mesenchymal tumor. However, a detailed analysis of the development of terminology suggests that the term "inflammatory myofibroblastic tumors" should be used to refer to a neoplastic lesion. Sep 27, 2021 · 1. IMT usually affects children and adolescents, although a broad age range has been documented. Epithelioid inflammatory myofibroblastic sarcoma (EIMS) is an aggressive subtype of IMT, typically involving the abdomen. Inflammatory myofibroblastic tumor (IMT) or plasma cell granuloma is a distinctive lesion composed of myofibroblastic spindle cells accompanied by an inflammatory Inflammatory myofibroblastic tumor (IMT) is a neoplasm of intermediate biologic potential. 29460. Mar 3, 2021 · An image of the tumor’s histology is seen above. ". The name of the disease was introduced 2 years later, and the tumors were described as characterized by proliferation of fibroblasts and myofibroblasts, accompanied by chronic inflammatory infiltration by lymphocytes, plasma cells, eosinophils and histiocytes [2]. The tumour is composed of an admixture of spindle-shaped and ovoid cells with a prominent inflammatory infiltrate (figures 2–3). Inflammatory lesions are often called pseudotumors. All the lesions were incidentally discovered at delivery or … Nov 8, 2023 · Inflammatory myofibroblastic tumor (IMT) is a locally aggressive mesenchymal tumor with lymphocyte infiltration [1–4], and myofibroblast spindle cell proliferation , that presents as a solitary lesion . [30] Inflammatory myofibroblastic tumour [31] Sep 15, 2021 · 3. 7% of all lung tumors. Only 150–200 cases are reported in the USA annually . World J Surg Oncol 12 : 186. Surgery is the treatment of choice for localized tumors. IMT is rare and its true incidence and prevalence remains unclear ( 1 ). IMTs are mostly found in children and young adults but can occur at any age. (B) Pulmonary inflammatory myofibroblastic tumor exhibiting distinct collagenous stroma with scattered plasma cell infiltrate. Aug 7, 2024 · Inflammatory myofibroblastic tumors (IMTs) occur throughout the body, but the lungs are the most commonly involved organs. Here we report a case of a 30 year old male who presented with a rapidly Jun 30, 2017 · Inflammatory myofibroblastic tumors of the uterus are rare, and although most have a favorable prognosis, a small subset exhibit extrauterine disease, recur, or cause death. 4. Jul 27, 2016 · Inflammatory myofibroblastic tumor (IMT) is a distinct mesenchymal neoplasm composed of spindled fibroblastic and myofibroblastic cells in a myxoid to collagenous stroma containing abundant lymphocytic and plasmacytic inflammatory infiltrate . R. Jul 11, 2013 · The term inflammatory myofibroblastic tumor (IMT) encompasses a diverse group of spindle cell entities that traverses a clinical and histologic spectrum, extending from reactive to benign neoplastic to highly aggressive with malignant inclinations. Apr 4, 2021 · These findings also demonstrate that this type of tumor is an independent entity that is different from inflammatory myofibroblastic tumors and dermatofibrosarcoma protuberans. (A) Long spindle cells contained small nuclei with vesicular chromatin and scattered plasma cells and lymphocytes. 4 Lesions are usually 0. Inflammatory myofibroblastic tumor was initially regarded as a benign tumor that most often developed in the lung and less commonly in almost any organ system or tissue. Introduction. Thompson, MD1 Inflammatory myofibroblastic tumor (IMT) is a distinc-tive, rarely metastasizing, (myo)fibroblastic neoplasm composed of spindle cells accompanied by an inflamma-tory infiltrate of plasma cells, lymphocytes, and/or eosi-nophils. Inflammatory myofibroblastic tumor (IMT) is a distinctive fibroblastic and myofibroblastic spindle c Clinicopathologic and Genomic Characterization of Inflammatory Myofibroblastic Tumors of the Head and Neck: Highlighting a Novel Fusion and Potential Diagnostic Pitfall : The American Journal of Surgical Pathology Jul 17, 2012 · Inflammatory myofibroblastic tumor is a rare benign lesion whose tumor origin is now proven. Over time, however, IMT cases occurred in which the tumor spread into local tissues, metastasized to distal tissues, recurred after treatment, or consisted of neoplastic cells Inflammatory myofibroblastic tumor (IMT) is a mesenchymal neoplasm of intermediate biological potential with a predilection for the lung and abdominopelvic region. Clinical, pathologic, and molecular features of inflammatory myofibroblastic tumors in children and adolescents Pediatr Blood Cancer . Jul 9, 2021 · Inflammatory myofibroblastic tumor of soft tissue is a histologically distinctive myofibroblastic spindle cell neoplasm of borderline malignancy, classically featuring an intermixture of plasma cells and lymphocytes. We report the case of a three-year-old child who suffered from a chronic cough with recurrent respiratory infections. Which of the following is the most likely diagnosis? High grade osteosarcoma Hodgkin lymphoma Inflammatory myofibroblastic tumor Myxoinflammatory fibroblastic sarcoma Mar 21, 2024 · A. IMT has a predilection for the lung, abdomen, pelvis, and retroperitoneum, however, can affect any part of the body. 15 Up to one-third of the IMT cases arise in the lungs 16 and 65% of cases involve the abdomen, retroperitoneum or pelvis. Head and neck IMTs are rarely seen and comprise less than 5 % of tumors. The histology shows spindle and epithelioid cells with eosinophilic cytoplasm, moderate pleomorphism but no mitotic activity and prominent nucleoli admixed with inflammatory cells characteristic of inflammatory leiomyosarcoma / inflammatory rhabdomyoblastic tumor. 2022 May;69(5):e29460. [29] Solitary fibrous tumour, also fibrous termed tumor of the pleura. A: Well demarcated firm vascularized tumor mass with spotty inflammatory infiltrate; B: Bland proliferation of spindle cells in broad fascicles at higher magnification. Learn more about treatment and the prognosis for IMT. Half of inflammatory myofibroblastic tumors (cases 1–6) showed a predominantly diffuse myxoid or edematous stroma with variably collagenized areas Mar 1, 2022 · Inflammatory pseudotumor (IPT) was first described in 1903 as a benign, non-infective, local lesion of the orbital region [1]. Patient characteristics, clinical features, histopathological results, immunohistochemical staining results, and treatment outcomes were reviewed. 4–3. It is also known as plasma cell granuloma, inflammatory myofibrohistiocytic proliferation, omental Objectives: To present the most important characteristics of inflammatory myofibroblastic tumours (IMTs) arising in different locations of the body with histological correlation. 3, 4 IMT primarily affects children Oct 1, 2014 · Inflammatory myofibroblastic tumor and other spindle cell lesions of the urinary bladder represent one of the most difficult diagnostic dilemmas in genitourinary pathology because of significant overlap between benign and malignant processes in terms of clinical presentation, gross findings, morphology, and immunoprofile. Due to the limited number of cases, the cytogenetic characteristics of SCPFT have not been determined, and only one report found t(2;5)(q31;q31) chromosomal Jun 20, 2024 · Inflammatory myofibroblastic tumor (IMT) is a rare neoplasm with intermediate malignancy characterized by a propensity for recurrence but a low metastatic rate. 1002/pbc. IMT is rare in the … Microscopic examination shows a dense inflammatory infiltrate with scattered atypical tumor cells with prominent nucleoli that resemble Reed-Sternberg cells. On ultrasonography (US), these tumours can appear as hypoechoic or hyperechoic masses and a Introduction: We report the clinical findings and results of treatment in the cohort of patients with inflammatory myofibroblastic tumor (IMT) managed according to the European pediatric Soft Tissue Sarcoma Study Group (EpSSG) protocol from 2005 to 2016. 1, 2, 3 Laryngeal IMT has been reported most commonly in the vocal folds, although a few cases in the aryepiglottic folds have been reported. Diagnostic challenges arise from the diverse pathological presentation, variable symptomatology, and lack of different imaging features. Jul 8, 2021 · Inflammatory myofibroblastic tumor (IMT) is a kind of mesenchymal tumor characterized with proliferation of myofibroblast spindle cells and prominent infiltration of plasmocytes and/or lymphocytes. A total of 75 case reports were included in the analysis. Surgery is the treatment of … Jul 7, 2021 · Inflammatory myofibroblastic tumor (IMT) is a kind of mesenchymal tumor characterized with proliferation of myofibroblast spindle cells and prominent infiltration of plasmocytes and/or lymphocytes. We studied 11 uterine IMTs with typical histology and 8 uterine myxoid smooth muscle tumors (5 leiomyomas, 1 smooth muscle tumor of uncertain malignant potential, and 2 leiomyosarcomas) in which the differential of IMT was considered, using a RNA-sequencing–based fusion assay to detect genetic fusions involving ALK, ROS1, RET, NTRK1/3, and other genes. 1, 2 IMT occurs most commonly in the lungs, gastrointestinal tract, and liver, but rarely arises in the larynx. ALK was expressed in 10 of Apr 12, 2021 · The diagnosis of benign and malignant soft tissue and bone neoplasms is a challenging area of surgical pathology, due to the large number, rarity, and histologic diversity of tumor types. DISCUSSION. 8 IMT of the larynx, trachea, kidney, urinary bladder Apr 13, 2011 · Inflammatory Myofibroblastic tumor (IMT) is a rare neoplasm consisting of variable numbers of inflammatory cells and myofibroblastic spindle cells. Dec 18, 2014 · Objectives To present the most important characteristics of inflammatory myofibroblastic tumours (IMTs) arising in different locations of the body with histological correlation. IMT represents the neoplastic subset of the family of inflammatory pseudotumors, an umbrella term for spindle cell proliferations of unc … Inflammatory pseudotumour is a generic term applied to a variety of neoplastic and non-neoplastic entities that share a common histological appearance, namely a cytologically bland spindle cell proliferation with a prominent, usually chronic inflammatory infiltrate. In this study, we report a subset of IMTs with histologic atypia and/or clinical aggressiveness that were analyzed for clinicopathologic features, outcome, and immunohistochemical expression of anaplastic lymp … Jul 20, 2023 · PATHOLOGY. Owing to its rarity, however, IMT remains poorly understood. Methods: To review the symptoms and main radiological findings of IMTs. Much of the confusion has been caused by the varying degrees of inflammatory cell infiltration noted on pathologic examination and the observation that the disease process, although usually Feb 12, 2015 · The World Health Organization (WHO) classifies inflammatory myofibroblastic tumors (IMTs) as distinct borderline lesions, while the physical history of these lesions can variably range from reactive to truly neoplastic . Inflammatory myofibroblastic tumor (IMT) is a neoplasm of intermediate biologic potential. There is significant controversy and confusion regarding the pathogenesis and histogenesis of these uncommon tumors or tumor-like masses . It represents 0. On ultrasonography (US), these tumours can appear as hypoechoic or hyperechoic masses and a variable Doppler appearance with increased vascularity Apr 19, 2016 · Inflammatory myofibroblastic tumor is a neoplasm of intermediate biological aggressiveness and is classified among the fibroblastic—myofibroblastic tumors. Immunohistochemistry shows ALK1 staining of the nuclear membranes. 1186/1477-7819-12-186 . Inflammatory leiomyosarcoma. In this study, we report a subset of IMTs with histologic atypia and/or clinical aggressiveness that were analyzed for clinicopathologic features, outcome, and immunohistochemical expression of anaplastic lymphoma kinase (ALK) and other markers to identify potential pathologic prognostic features. We describe the clinical, pathologic, and molecular findings in nine cases of placenta-associated IMT (PaIMT). Chest X-ray and computed tomography revealed the presence of a left lower lobe lung mass. IMTs are one of the most frequent lung tumors in children, accounting for between 16% and 38% of cases in various series. We reviewed data from eight patients diagnosed with pulmonary IMT (PIMT) at our hospital with the aim of summarizing and analyzing the characteristics of PIMT to improve our understanding of May 23, 2022 · Inflammatory myofibroblastic tumor (IMT) is a heterogeneous malignancy with variable patterns of histology and behavior that primarily affects children and young adults. [1-3] Jan 16, 2020 · Inflammatory Myofibroblastic Tumor. Inflammatory myofibroblastic tumor (IMT) is terminology for neoplastic lesions. Modern Pathology Dec 28, 2023 · Inflammatory myofibroblastic tumour (IMT) is a rare mesenchymal neoplasm of intermediate malignant potential, occurring at any age and at multiple sites. IMT usually starts in the lung, but it can also begin in many other places. It is an ultra-rare tumor, the optimal management of which remains to be defined. Dec 14, 2018 · Pathology and immunohistochemistry analysis is the key to the diagnosis of primary gastric myofibroblastic tumors, especially ALK, which can be used as an identifying factors for IMT and gastrointestinal stromal tumors (GISTS), smooth muscle neoplasm, inflammatory fibrous polyps, solitary fibrous tumor, peripheral nerve sheath tumors Aug 1, 2021 · Section snippets Clinical presentation. What molecular abnormality is present in this tumor? Histology of inflammatory myofibroblastic tumour. doi : 10. 1 It is a soft tissue tumor, which evolves through myofibroblastic differentiation and is characterized by the infiltration of inflammatory cells into the tissue. A number of terms have been applied to the lesion, namely, inflammatory Nov 5, 2019 · Two main histologic patterns were identified. Genetically, most IMTs harbor tyrosine Jul 27, 2022 · An inflammatory myofibroblastic tumor (IMT) is a neoplasm composed of myofibroblastic and fibroblastic spindle cells accompanied by inflammatory cells, including lymphocytes and eosinophils. These tumors have been divided into the following categories on the basis of their biologic behavior: benign (eg, myositis ossificans, myofibroma, fibromatosis colli), intermediate–locally aggressive (eg, lipofibromatosis The terms "inflammatory myofibroblastic tumors" and "inflammatory pseudotumors" are interchangeably used by many scientists. IMT is typi … "An inflammatory myofibroblastic tumor exhibiting immunoreactivity to KIT: a case report focusing on a diagnostic pitfall. Dec 18, 2014 · To present the most important characteristics of inflammatory myofibroblastic tumours (IMTs) arising in different locations of the body with histological correlation. In recent years, diagnosis and classification has been aided substantially Inflammatory myofibroblastic tumors (IMTs) of the uterus are often associated with pregnancy and are delivered with the placenta. in 1954 because of its clinical and radiological behavior that mimics a malignant process [ 1 ]. The tumor is composed of spindle-shaped myofibroblasts with fascicles or storiform patterns and sometimes within loose myxoid stroma. Over the last two decades, inflammatory myofibroblastic tumour (IMT) has emerged from within the broad category of inflammatory Jul 11, 2013 · The lack of necrosis and absence of staining for CD23 used as a substitute for CD21, further confirmed the exclusion of nodular fasciitis and follicular dendritic tumor, respectively. Dec 1, 2021 · Inflammatory myofibroblastic tumor (IMT) is a distinctive fibroblastic and myofibroblastic spindle cell neoplasm with an accompanying inflammatory cell infiltrate and frequent receptor tyrosine kinase activation at the molecular level. Jul 27, 2022 · An inflammatory myofibroblastic tumor (IMT) is a neoplasm composed of myofibroblastic and fibroblastic spindle cells accompanied by inflammatory cells, including lymphocytes and eosinophils. Aug 12, 2022 · Inflammatory myofibroblastic tumor (IMT) is a rare myofibroblastic neoplasm that most frequently occurs in children and young adults. Jul 1, 2023 · Approximately half of inflammatory myofibroblastic tumors harbor anaplastic lymphoma kinase (ALK) fusion genes, and the other half could have potentially targetable fusion genes or mutations such as ROS1, NTRK and RET; case reports demonstrating the clinical efficacy of treatments targeted to inflammatory myofibroblastic tumor have been Nov 18, 2020 · Cytomorphological analysis of an inflammatory myofibroblastic tumor. To review the symptoms and main radiological findings of IMTs. Mar 6, 2013 · Department of Pathology, Central University Hospital, 33306 Oviedo, Spain. Inflammatory myofibroblastic tumor (IMT) is a rare benign lesion that has similarities to malignant lesions due to possible aggressive behavior, although its specific potential for malignancy has not been determined. Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal tumor of intermediate malignant potential that predominantly affects children, adolescents and young adults. The median age at diagnosis is 9 years of age 2, 14 with a female to male ratio of 1. Previously termed “inflammatory pseudotumor” (among many other names), inflammatory myofibroblastic tumor (IMT) is a myofibroblastic neoplasm of intermediate biologic potential that arises predominantly in children, adolescents, and young adults in the lungs, abdomen, and pelvis [74, 75]. Also known as pseudosarcoma, atypical myfibroblastic tumor, atypical fibromyxoid tumor, plasma cell granuloma. ). 14 IMT can occur at any site and presenting symptoms vary based on primary site of the IMT. 5 cm in size. IMTs show characteristic fasciitis-like, compact spindle cell and hypocellular fibrous histologic patterns and distinctive molecular features. Inflammatory myofibroblastic tumor (Pathol Res Pract 2023;242:154335) Interdigitating dendritic cell sarcoma (Am J Surg Pathol 2002;26:530) Leiomyoma (usually) and vascular leiomyoma (Am J Surg Pathol 2001;25:1355, J Clin Pathol 2002;55:395) Leiomyosarcoma (usually) (Arch Pathol Lab Med 2017;141:1072) Oct 1, 2006 · Inflammatory myofibroblastic tumor may mimic a malignant neoplasm both clinically and radiographically; however, following complete surgical resection, these tumors generally behave in an indolent fashion. It encompasses a spectrum of myofibroblastic proliferation along with varying amount of inflammatory infiltrate. Imaging findings reflect pathologic features and vary from an ill-defined, infiltrating lesion to a wellcircumscribed, soft tissue mass owing to variable inflammatory, stromal, and myofibroblastic Inflammatory myofibroblastic tumor, or IMT, forms in tissues called mucosal surfaces and mesentery. The tumor may recur and rarely metastasizes. Inflammatory myofibroblastic tumor is an uncommon lesion of unknown cause. Magnification Jul 4, 2024 · Introduction: Inflammatory pseudotumor encompasses a broad range of non-neoplastic and neoplastic entities, including inflammatory myofibroblastic tumors (IMTs). doi: 10. Inflammatory myofibroblastic tumor of the breast is an extremely rare lesion. 2 Nonetheless, rare cases with local recurrence and aggressive clinical course have been reported, especially in the small subset of patients Jan 3, 2018 · This review covers prostatic stromal proliferations (prostatic stromal tumor of uncertain malignant potential and stromal sarcoma), solitary fibrous tumor, myofibroblastic proliferations, smooth Dermatofibrosarcoma protuberans, fibrosarcomatous, also termed fibrosarcomatous dermatofibrosarcoma protuberans (or fibrosarcomatous DFSP), is a more aggressive tumor than dermatofibrosarcoma protuberans tumors). . Inflammatory myofibroblastic tumor (IMT) is a Aug 17, 2022 · Inflammatory myofibroblastic tumor (IMT) is a rare disease. terine IMT. Jul 11, 2016 · Pediatric fibroblastic and myofibroblastic tumors are a relatively common group of soft-tissue proliferations that are associated with a wide spectrum of clinical behavior. Mar 3, 2022 · A database searches in the pathology archives by using the term “inflammatory myofibroblastic tumor” and” bladder” in our hospital department of pathology from 2010 to 2021. The treatment of advanced disease is not precisely defined Apr 4, 2020 · Postoperative microscopic pathology of the inflammatory myofibroblastic tumors. Search for more papers by this author. Histologically, the lesion is based in the dermis and seen underlying a normal epidermis (figure 1). It was first observed in the lung and described by Brunn in 1939 and was so named by Umiker et al. Because it is a rare mesenchymal tumor of unknown etiology and pathogenesis, and its clinical symptoms and radiologic features are not distinctive, intracranial IMT could be misdiagnosed as other extra-axial tum Methods: A PubMed/Medline search was conducted, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, using the following Mesh terms: ("inflammatory myofibroblastic") AND ("tumor") OR ("tumor") AND ("bladder") AND ("case report"). Magnification, ×400. Methods. Methods To review the symptoms and main radiological findings of IMTs. After pneumonectomy, histological examination combined Pathology Clinic Inflammatory Myofibroblastic Tumor Lester D. nndlpya uykqgwj jkd ckd xtxbi auws jlmekqpb cytlxef mcaqfh blosvxm